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  • Articles  (89)
  • Geosciences  (61)
  • Natural Sciences in General  (28)
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  • Articles  (89)
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  • 1
    Publication Date: 2014-02-28
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 2
    Publication Date: 2013-07-23
    Description: Subduction initiation at passive margins plays a central role in the plate tectonics theory. However, the process by which a passive margin becomes active is not well understood. In this paper we use the southwest Iberia margin (SIM) in the Atlantic Ocean to study the process of passive margin reactivation. Currently there are two tectonic mechanisms operating in the SIM: migration of the Gibraltar Arc and Africa-Eurasia convergence. Based on a new tectonic map, we propose that a new subduction zone is forming at the SIM as a result of both propagation of compressive stresses from the Gibraltar Arc and stresses related to the large-scale Africa-Eurasia convergence. The Gibraltar Arc and the SIM appear to be connected and have the potential to develop into a new eastern Atlantic subduction system. Our work suggests that the formation of new subduction zones in Atlantic-type oceans may not require the spontaneous foundering of its passive margins. Instead, subduction can be seen as an invasive process that propagates from ocean to ocean.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
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  • 3
    Publication Date: 2015-01-16
    Description: The monoterpenes are the main constituents of most essential oils and p-cymene is a monoterpene commonly found in various species of aromatic herbs, which has been reported for anti-inflammatory, antinociceptive, and antimicrobial activities. However, there is no report concerning its pharmacological activity on the vascular smooth muscle. The aim of current work was to investigate the effects of p-cymene in isolated rat aorta and also study its mechanism of action. In this work, we show that p-cymene has a relaxant effect, in a dose-dependent way, on the vascular smooth muscle, regardless of the presence of the endothelium. Using a nonselective potassium channel blocker, the CsCl, the relaxant effect of p-cymene was attenuated. In the presence of more selective potassium channels blockers, such as TEA or 4-AP, no change in the relaxant effect of p-cymene was evidenced, indicating that and channels are not involved in that relaxant effect. However, in the presence of glibenclamide or BaCl2, and blockers, respectively, the relaxant effect of p-cymene was attenuated. The data presented indicate that p-cymene has a relaxing effect on rat aorta, regardless of the endothelium, but with the participation of the and channels.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 4
    Publication Date: 2016-03-24
    Description: Crystal Growth & Design DOI: 10.1021/acs.cgd.6b00159
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
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  • 5
    Publication Date: 2016-06-02
    Description: Threatened by mining, polymetallic nodules are required to preserve abyssal epifauna Scientific Reports, Published online: 1 June 2016; doi:10.1038/srep26808
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 6
    Publication Date: 2015-02-18
    Description: Crystal Growth & Design DOI: 10.1021/cg5017388
    Print ISSN: 1528-7483
    Electronic ISSN: 1528-7505
    Topics: Chemistry and Pharmacology , Geosciences , Physics
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  • 7
    Publication Date: 2014-12-20
    Description: El granito de Pedregal aflora en la Zona Centro-Ibérica, en el norte de Portugal, en el borde oriental de un complejo granito-migmatítico sinorogénico varisco, subconcordante con las estructuras metamórficas regionales. Es un granitoide (ca. 3 km 2 ) de forma elongada NW-SE, que intruye en micaesquistos estaurolíticos y en rocas gneissico- migmatíticas bandeadas, con brechas ígneas locales en el contacto. Las rocas encajantes pertenecen a una secuencia metapelítica-metasamítica de edad Ediacariense - Cámbrico, conocida como el “Complejo Esquisto-Grauváquico” (CEG), que muestra una foliación regional principal NW-SE a NNW- SSE. El granito de Pedregal es peralumínico (el parámetro A/CNK oscila desde 1.18 hasta 1.62), con una composición magnesiana, entre alcalina y alcalino-cálcica. Sus características peculiares son el alto contenido de Zr (389–435 ppm) y de tierras raras ligeras (LREE) que presentan un patrón plano, la forma corroída de la biotita, y la gran cantidad de moscovita secundaria. Estas características peculiares lo distinguen de los otros granitos sinorogénicos adyacentes. Las características de campo, petrográficas y químicas del granito de Pedregal parecen apuntar a una segunda fase de fusión parcial de un residuo, empobrecido por la segregación de fundido durante una primera fase de fusión con participación de granate peritéctico y abundante biotita residual con minerales accesorios portadores de LREE y Zr. Además, el carácter intrusivo del granito, y la presencia de xenolitos metasedimentarios sugieren una diatexita secundaria.
    Print ISSN: 0367-0449
    Electronic ISSN: 1988-3250
    Topics: Geosciences
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  • 8
    Publication Date: 2008-10-17
    Description: Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of the most frequent solid tumours in childhood. It usually occurs sporadically but familial cases are observed, with a subset of cases occurring in association with congenital malformations of the neural crest being linked to germline mutations of the PHOX2B gene. Here we conducted genome-wide comparative genomic hybridization analysis on a large series of neuroblastomas. Copy number increase at the locus encoding the anaplastic lymphoma kinase (ALK) tyrosine kinase receptor was observed recurrently. One particularly informative case presented a high-level gene amplification that was strictly limited to ALK, indicating that this gene may contribute on its own to neuroblastoma development. Through subsequent direct sequencing of cell lines and primary tumour DNAs we identified somatic mutations of the ALK kinase domain that mainly clustered in two hotspots. Germline mutations were observed in two neuroblastoma families, indicating that ALK is a neuroblastoma predisposition gene. Mutated ALK proteins were overexpressed, hyperphosphorylated and showed constitutive kinase activity. The knockdown of ALK expression in ALK-mutated cells, but also in cell lines overexpressing a wild-type ALK, led to a marked decrease of cell proliferation. Altogether, these data identify ALK as a critical player in neuroblastoma development that may hence represent a very attractive therapeutic target in this disease that is still frequently fatal with current treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janoueix-Lerosey, Isabelle -- Lequin, Delphine -- Brugieres, Laurence -- Ribeiro, Agnes -- de Pontual, Loic -- Combaret, Valerie -- Raynal, Virginie -- Puisieux, Alain -- Schleiermacher, Gudrun -- Pierron, Gaelle -- Valteau-Couanet, Dominique -- Frebourg, Thierry -- Michon, Jean -- Lyonnet, Stanislas -- Amiel, Jeanne -- Delattre, Olivier -- England -- Nature. 2008 Oct 16;455(7215):967-70. doi: 10.1038/nature07398.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, Centre de Recherche, and Inserm, U830, 26 rue d'Ulm, Paris F-75248, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18923523" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Cell Line, Tumor ; Child ; Gene Dosage ; Genome, Human/genetics ; Germ-Line Mutation/*genetics ; Humans ; Neuroblastoma/enzymology/*genetics ; Nucleic Acid Hybridization ; Phosphorylation ; Point Mutation/*genetics ; Polymorphism, Single Nucleotide/genetics ; Protein-Tyrosine Kinases/chemistry/deficiency/*genetics/metabolism ; Receptor Protein-Tyrosine Kinases
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2005-08-27
    Description: Strong friction anisotropy is found when the twofold surface of an atomically clean aluminum-nickel-cobalt quasicrystal slides against a thiol-passivated titanium-nitride tip. Friction along the aperiodic direction is one-eighth as much as that along the periodic direction. This anisotropy, which is about three times as large as the highest value observed in anisotropic crystalline surfaces, disappears after the surface is oxidized in air. These results reveal a strong connection between interface atomic structure and the mechanisms by which energy is dissipated, which likely include electronic or phononic contributions, or both.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Park, Jeong Young -- Ogletree, D F -- Salmeron, M -- Ribeiro, R A -- Canfield, P C -- Jenks, C J -- Thiel, P A -- New York, N.Y. -- Science. 2005 Aug 26;309(5739):1354-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Materials Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16123295" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
    Publication Date: 2014-10-09
    Description: Classical novae are the most common astrophysical thermonuclear explosions, occurring on the surfaces of white dwarf stars accreting gas from companions in binary star systems. Novae typically expel about 10(-4) solar masses of material at velocities exceeding 1,000 kilometres per second. However, the mechanism of mass ejection in novae is poorly understood, and could be dominated by the impulsive flash of thermonuclear energy, prolonged optically thick winds or binary interaction with the nova envelope. Classical novae are now routinely detected at gigaelectronvolt gamma-ray wavelengths, suggesting that relativistic particles are accelerated by strong shocks in the ejecta. Here we report high-resolution radio imaging of the gamma-ray-emitting nova V959 Mon. We find that its ejecta were shaped by the motion of the binary system: some gas was expelled rapidly along the poles as a wind from the white dwarf, while denser material drifted out along the equatorial plane, propelled by orbital motion. At the interface between the equatorial and polar regions, we observe synchrotron emission indicative of shocks and relativistic particle acceleration, thereby pinpointing the location of gamma-ray production. Binary shaping of the nova ejecta and associated internal shocks are expected to be widespread among novae, explaining why many novae are gamma-ray emitters.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chomiuk, Laura -- Linford, Justin D -- Yang, Jun -- O'Brien, T J -- Paragi, Zsolt -- Mioduszewski, Amy J -- Beswick, R J -- Cheung, C C -- Mukai, Koji -- Nelson, Thomas -- Ribeiro, Valerio A R M -- Rupen, Michael P -- Sokoloski, J L -- Weston, Jennifer -- Zheng, Yong -- Bode, Michael F -- Eyres, Stewart -- Roy, Nirupam -- Taylor, Gregory B -- England -- Nature. 2014 Oct 16;514(7522):339-42. doi: 10.1038/nature13773. Epub 2014 Oct 8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824, USA. ; 1] Department of Earth and Space Sciences, Chalmers University of Technology, Onsala Space Observatory, SE-439 92 Onsala, Sweden [2] Joint Institute for VLBI in Europe, Postbus 2, NL-7990 AA Dwingeloo, The Netherlands [3] Shanghai Astronomical Observatory, Chinese Academy of Sciences, 80 Nandan Road, 200030 Shanghai, China. ; Jodrell Bank Centre for Astrophysics, Alan Turing Building, University of Manchester, Manchester M13 9PL, UK. ; Joint Institute for VLBI in Europe, Postbus 2, NL-7990 AA Dwingeloo, The Netherlands. ; National Radio Astronomy Observatory, PO Box O, Socorro, New Mexico 87801, USA. ; Space Science Division, Naval Research Laboratory, Washington, DC 20375-5352, USA. ; 1] Department of Physics, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA [2] CRESST and X-ray Astrophysics Laboratory, NASA/GSFC, Greenbelt, Maryland 20771, USA. ; School of Physics and Astronomy, University of Minnesota, 115 Church Street Southeast, Minneapolis, Minnesota 55455, USA. ; Astrophysics, Cosmology and Gravity Centre, Department of Astronomy, University of Cape Town, Private Bag X3, Rondebosch 7701, South Africa. ; 1] National Radio Astronomy Observatory, PO Box O, Socorro, New Mexico 87801, USA [2] National Research Council, Herzberg Astronomy and Astrophysics, 717 White Lake Road, PO Box 248, Penticton, British Columbia V2A 6J9, Canada. ; Columbia Astrophysics Laboratory, Columbia University, New York, New York 10027, USA. ; Astrophysics Research Institute, Liverpool John Moores University, IC2, Liverpool Science Park, 146 Brownlow Hill, Liverpool L3 5RF, UK. ; Jeremiah Horrocks Institute for Mathematics, Physics and Astronomy, University of Central Lancashire, Preston PR1 2HE, UK. ; Max-Planck-Institut fur Radioastronomie, Auf dem Hugel 69, D-53121 Bonn, Germany. ; Department of Physics and Astronomy, University of New Mexico, MSC07 4220, Albuquerque, New Mexico 87131-0001, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25296250" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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