ISSN:
1573-4935
Keywords:
virus inhibitors
;
measles virus
;
peptide synthesis
;
membrane fusion
;
membrane stabilization
;
hexagonal phase
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract A number of carbobenzoxy-dipeptide-amides raise the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine (stabilizes the bilayer). The potency of the peptides in stabilizing the bilayer phase is Z-Tyr-Leu-NH2= Z-Gly-Phe-NH2〉Z-Ser-Leu-NH2〉Z-Gly-Leu-NH2〉Z-Gly-Gly-NH2. A linear correlation was found between the respective HPLC retention time parameterk′ for the peptide and the slope of the bilayer stabilization curve determined with model membranes by differential scanning calorimetry. One dipeptide, Z-Ser-Leu-NH2, reduces measles virus cytopathic effect (CPE) in Vero cells. The mechanism by which this peptide reduces the CPE is not known, although some peptides which raise the bilayer to hexagonal phase transition temperature of phospholipids inhibit membrane fusion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01116868
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