ISSN:
1573-904X
Keywords:
N-alkalyl-1,2-diphenylethanolamines, antiarrhythmic activity
;
phenethylamines
;
α-phenyl, β-hydroxy antiarrhythmic activity
;
verapamil
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2–8 µmol kg−1 protected the animals against the induced arrhythmia. The potency order was verapamil 〉 N methyl 〉 N-ethyl 〉 N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015925803166
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