ISSN:
1432-1041
Keywords:
hepatic cirrhosis
;
aminophylline
;
renal blood flow
;
renal function
;
sodium handling
;
diuresis
;
tubular absorption
;
free water production
;
vasoconstriction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In 18 cirrhotics with impaired renal perfusion intravenous injection of aminophylline 3 mg/kg b.w. increased mean renal blood flow (133-Xenon washout) from 1.77±0.71 to 1.99±0.44 ml/g/min (p〈0.01). No significant change in cardiac output was found. In a further 10 cirrhotic patients the administration of aminophylline 3 mg/kg decreased the mean tubular reabsorption of sodium in the proximal section of the nephron (distal delivery) from 10.5±6.2 to 16.3±16.5 (p〈0.01). Free-water production increased as a consequence of the increased supply of sodium to the diluting segment. Thus, aminophylline acts favourably on the functional renal impairment that occurs in hepatic cirrhosis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00607083
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