ISSN:
1436-5073
Keywords:
hydrates
;
norfloxacin
;
thermodynamically stable
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Norfloxacin, a nalidixic acid analog with antimicrobial properties, exists in different hydrated forms. Three of these crystal forms were reproducibly prepared and characterized by analytical techniques that included infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, solution microcalorimetry and pulsed nuclear-magnetic resonance spectroscopy. These studies showed that the dihydrate is the thermodynamically stable entity at ambient temperatures and humidities.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01196816
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