ISSN:
0730-2312
Keywords:
steroid hormone receptors
;
antihormones
;
conformational change
;
gene transcription
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Steroid hormones are involved in cell growth, development, and differentiation. The hormonal signal is mediated by nuclear receptors which represent a specific class of transcription factors. During the last few years, the cloning of all the major steroid hormone receptors increased our insight into how the hormonal signal converts the receptor into a transcriptional activator. Good progress has been made towards understanding the mechanism of steroid hormone action. In this review we will discuss the role of heat shock proteins in the process of transcriptional activation, the mechanistic differences between the hormone (agonist) and the antihormone (antagonist), the resulting functional consequences, and a possible mode by which transcriptional activation is mediated. © 1993 Wiley-Liss, Inc.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcb.240510206
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