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  • 1
    Electronic Resource
    Electronic Resource
    Analysis of Aluminum—Yeast Hexokinase Interaction: Modifications on Protein Structure and Functionality (2000)
    Springer
    The protein journal 19 (2000), S. 199-208 
    Details
    ISSN: 1573-4943
    Keywords: Aluminum ; yeast hexokinase ; preferential interactions ; kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The aluminum and yeast hexokinase interaction was studied. Structural changes were correlated with variations in protein functionality. Results show two different behaviors: At low metal concentrations preferential adsorption of metal (and water exclusion) induces aggregate formation. No significant changes in the protein structure occur, but there is a continuous loss of activity (from the first concentration). At large salt concentrations a monomerization process and a conformational change in the secondary structure as well as in the three-dimensional structure take place. This change reduces the percentage of α-helix conformation, gives thermal stability to the protein, and allows the exposure of some tryptophan residue and hydrophobic regions. The protein inhibition increases. Conformational change and monomerization may allow access of the metal to the substrate site, mainly the ATP site. The inhibition in any case is of mixed type with a competitive component.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007055719926
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  • 2
    Electronic Resource
    Electronic Resource
    Preferential interactions of poly(N-vinyl-2-pyrrolidone) in the binary mixture water/CdCl2 (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Polymer International 36 (1995), S. 345-351 
    Details
    ISSN: 0959-8103
    Keywords: viscometry ; densimetry ; unperturbed dimensions ; preferential interactions ; poly(N-vinyl-2-pyrrolidone) ; CdCl2 ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The poly(N-vinyl-2-pyrrolidone)(PVP)(2)/water(1)/CdCl2(3) ternary system has been studied by viscometry, densimetry and atomic absorption spectrophotometry. In this system a preferential adsorption of Cd2+ at all solvent compositions studied and a conformational transition at 4mM of salt, the concentration at which a preferential adsorption minimum of Cd2+ in exhibited, are observed. The PVP/Cd2+ bound molar ratio is 0·23. CdCl2 behaves as a salting-in agent for the macromolecule. The binary solvent mixture is thermodynamically more favourable at salt concentrations greater than 10 mM of CdCl2.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pi.1995.210360407
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