ISSN:
1432-1041
Keywords:
aspirin
;
paracetamol
;
plasma aspirin esterase activity
;
bleeding time
;
platelet aggregation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Following 1 g aspirin there was a significant increase in bleeding time at 24 h (p〈0.01). A significant reduction (P〈0.01) in platelet aggregation with collagen was observed at 1, 6 and 24 h after aspirin, but no significant reduction (P〉0.05) was observed with ADP. Paracetamol had no effect on bleeding time or platelet aggregation. Plasma aspirin esterase activity ranged from 0.26–0.6 µmol/ml/min. A significant negative correlation (R=−0.55, P〈0.001) was observed between percentage increase in bleeding time (24 h) and plasma aspirin esterase activity. Further significant correlations were observed between plasma aspirin esterase activity and change in platelet aggregation with collagen at 1 h (R=0.68, P〈0.001), 6 h (R=−0.73, P〈0.001) and 24 h (R=−0.67, P〈0.001). These results suggest that it might be possible to predict an individual's haemostatic response to aspirin from knowledge of their plasma aspirin esterase activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00543486
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