ISSN:
1432-1041
Schlagwort(e):
Biguanides
;
butylbiguanide
;
pharmacokinetics
;
sustained release form
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary In man, after oral administration of 50 mg14C-butylbiguanide, the maximum serum concentration was 26–41 µg/100 ml. The biguanide was eliminated with an average half-life of 2h. 84% of the dose administered was found excreted unchanged in the urine. — After administration of14C-butylbiguanide in a sustained release form (Silubin® retard), the drug was slowly released and its serum concentration remained almost constant for up to 7 h.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00565010
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