ISSN:
1573-0832
Keywords:
Autoclaved Paracoccidioides brasiliensis
;
Digestion of killed fungi
;
leukocyte digestive defect
;
Paracoccidioides brasiliensis
;
paracoccidioidomycosis
;
neutrophils
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract We previously described an in vitro assay showing that neutrophils (PMNs) from patients with paracoccidioidomycosis (PARA) have a specific digestive deficiency against suspensions of live Paracoccidioides brasiliensis. We now report that this defect is equally detectable against autoclaved, but not Amphotericin B-killed P. brasiliensis. The use of autoclaved suspensions facilitates the use of our in vitro assay. It might allow the development of an in vitro intradermal test for digestion of fungi. Differential digestive ability of phagocytes against live (or autoclaved) and Amphotericin-B killed fungi is of conceptual interest. It may be relevant in understanding therapeutic effect of Amphotericin B.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00436927
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