ISSN:
0268-2605
Schlagwort(e):
organotin
;
solid-state NMR
;
crystal structure
;
antitumor activity
;
Chemistry
;
Industrial Chemistry and Chemical Engineering
Quelle:
Wiley InterScience Backfile Collection 1832-2000
Thema:
Chemie und Pharmazie
Notizen:
Bis(dicyclohexylammonium) bis(2,6-pyridinedicarboxylato)dibutylstannate is assigned seven-fold coordination at tin on the basis of its 119Sn CP/MAS NMR chemical shift (δ=-424.9 ppm). The assignment has been corroborated by a crystal structure determination of its monohydrate, whose tin atom has the trans-C2SnNO4 pentagonal bipyramidal [Sn-C=2.040(9), 2.067(8) Å; C-Sn-C =168.9(5)°] geometry. One 2,6-pyridine- dicarboxylato group chelates to the tin atom (Sn-O=2.234(4), 2.260(4); Sn-N =2.279(5) Å) whereas the other binds through only one carboxyl -CO2 end (Sn-O=2.416(5), 2.441(5) Å). Hydrogen bonds link the cation and the stannate into a linear chain parallel to the b-axis. The lattice water molecule is hydrogen-bonded to the free carboxyl end. The anhydrous compound showed higher in vitro antitumor activity than those of carboplatin and cisplatin when screened against breast (MCF-7, EVSAT), colonic (WiDr), ovarian (IGROV) and renal (A498) carcinoma, and melanoma (M19 MEL) cell lines. © 1997 by John Wiley & Sons, Ltd.
Zusätzliches Material:
2 Ill.
Materialart:
Digitale Medien
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