ISSN:
0730-2312
Keywords:
myc-related genes
;
nucleotide sequence
;
transformation
;
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
The myc family of cellular oncogenes contains three well-defined members: c-myc, N-myc and L-myc. Additional structural and functional evidence now suggests that other myc-family oncogenes exist. The overall structure and organization of the c-, N-. and L-myc genes and transcripts are very similar. Each gene contains three exons: encoding a long 5′ untranslated leader and a long 3′ untranslated region. The proteins encoded by these myc genes share several stretches of significant homology. The conservation of sequences at the carboxy-terminus of the L-myc protein suggests that it is also a DNA-binding, nuclear-associated protein. Each myc gene will cooperate with an activated Ha-ras oncogene to cause transformation of primary rat embryo fibroblasts. Characteristics of several new myc-family members are described.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcb.240330404
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