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A comparison of the binding of drugs to adult and cord plasma (1971)

Pruitt, A. W. ; Dayton, P. G.

Springer

European journal of clinical pharmacology 4 (1971), S. 59-62

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ISSN: 1432-1041

Keywords: Protein-binding ; newborns ; diphenylhydantoin ; imipramine ; diazoxide ; cephalotin ; cephaloglycin

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The binding of diphenylhydantoin, imipramine, diazoxide, cephalothin and cephaloglycin to adult and cord plasma is compared. The free (unbound) fraction of diphenylhydantoin, imipramine and diazoxide in cord plasma is greater than in adult plasma. Although total protein concentration of cord plasma is significantly lower than in adult plasma, this does not satisfactorily explain the lesser binding of these drugs to cord plasma.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00568901

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