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  • 1
    Electronic Resource
    Electronic Resource
    The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. III. Application to a Series of Substituted Pyridines (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 732-736 
    Details
    ISSN: 1573-904X
    Keywords: membrane diffusion ; linear free energy relationships ; partition coefficient ; molecular volume ; diffusion prediction ; pyridines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The steady-state flux of 35 substituted pyridine derivatives was determined in polydimethylsiloxane membranes using isopropyl alcohol as the receiver solvent. These diffusants constituted a diverse group of compounds possessing a wide range of hydrophobic, steric, and electronic characteristics. Various parameters representing these physicochemical properties such as cyclohexane–water fragmental constants, molar refractivity, Hammett's σ constants, melting point, and mole fraction solubility were employed to develop empirical models capable of relating the flux to these characteristics of either the substituent on the pyridine ring or the compound itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018968001793
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  • 2
    Electronic Resource
    Electronic Resource
    The Development of a Predictive Method for the Estimation of Flux Through Polydimethylsiloxane Membranes. IV. Application to a Series of Substituted Quinolines (1993)
    Springer
    Pharmaceutical research 10 (1993), S. 839-842 
    Details
    ISSN: 1573-904X
    Keywords: membrane diffusion ; linear free energy relationships ; partition coefficient ; molecular volume ; diffusion prediction ; quinolines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The steady-state flux of 33 substituted quinoline derivatives was determined in polydimethylsiloxane membranes using isopropyl alcohol as the receiver solvent. These diffusants constituted a diverse group of compounds possessing a wide range of hydrophobic, steric, and electronic characteristics. Various parameters representing these physicochemical properties such as cyclohexane–water fragmental constants, molar refractivity, Hammett's σ constants, intramolecular hydrogen bonding ability, melting point, and mole fraction solubility were employed to develop empirical models capable of relating the rate of diffusion to these characteristics of either the substituent on the quinoline ring or the compound itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018953025900
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    Paper (German National Licenses)
    Fulltext
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