ISSN:
1573-6881
Keywords:
Heart
;
excitation-contraction coupling
;
calcium
;
mitochondrial permeability transition pore
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract Mitochondria have been implicated in intracellular Ca2+ signaling in many cell types. Theinner mitochondrial membrane contains Ca2+-transporting proteins, which catalyze Ca2+ uptakeand extrusion. Intramitochondrial (matrix) Ca2+, in turn, regulates the activity of Krebs cycledehydrogenases and, ultimately, the rate of ATP synthesis. In the myocardium, controversyremains whether the fast cytosolic Ca2+ transients underlying excitation-contraction couplingin beating cells are rapidly transmitted into the matrix compartment or slowly integratedby the mitochondrial Ca2+ transporters. This mini-review critically summarizes the recentexperimental work in this field.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005556227425
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