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  • mineralocorticoids  (1)
  • tissue content  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    o, P'-DDD (mitotane) treatment for Cushing's syndrome: Adrenal drug concentration and inhibition in vitro of steroid synthesis (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 483-487 
    Details
    ISSN: 1432-1041
    Schlagwort(e): o,p'-DDD ; Cushing syndrome ; adrenal ; steroid synthesis ; mitotane ; tissue content ; dose-response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary o,p'-DDD is an inhibitor of adrenal steroid synthesis currently used for therapy of Cushing's syndrome. Conflicting data have been published on the relationship between the plasma level of the drug and its clinical and biological effects. The levels of o,p'-DDD and o,p'-DDE in various tissues obtained from treated patients have been measured and are compared with data on in vitro steroidogenesis in adrenal tissues from the same patients. o,p'-DDD was found in all samples and o,p'-DDE in half of them, both levels being high when the tissue lipid concentration was high. There was considerable variability in lipid content from one tissue to another and within a tissue from one sample to another; only the drug to lipid ratio seems able to provide a reproducible index of drug entry into a tissue. No relationship was found between the tissue concentration of the drug and the total dose administered or inhibition of the steroid biosynthetic step studied.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613466
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Lack of effect in vivo of clofibrate on adrenal steroid secretion (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 87-89 
    Details
    ISSN: 1432-1041
    Schlagwort(e): clofibrate ; hyperlipidaemia ; glucocorticoids ; mineralocorticoids ; progesterone ; aldosterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Clofibrate inhibits the synthesis of adrenal steroids when administered in vitro. In the present study the effect in vivo of clofibrate on adrenal steroid secretion has been investigated. Basal levels of plasma progesterone, corticosterone, aldosterone, 17-hydroxyprogesterone, 11-deoxycortisol, cortisol, dehydroepiandrosterone sulphate and dehydroepiandrosterone, and their response to ACTH 1 mg im, were not reduced by chronic administration of clofibrate 2 g per day p.o. for 8 to 34 days to 6 hyperlipidaemic men.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00561031
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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