ISSN:
0268-2605
Keywords:
Arsenic
;
metabolism
;
Candida humicola
;
methylarsines
;
methylarsine oxide
;
methylarsine sulfide
;
micro-organisms
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Methylarsine oxide and sulfide are more toxic to Candida humicola than arsenite; the sulfide is rapidly metabolized to trimethylarsine (Me3As) and methylarsine (MeAsH2) and the oxide to dimethylarsinic acid [Me2AsO(OH)]. Cell-free extracts of C. humicola also convert the oxide to Me2AsO(OH). The glutathione (RSH) derivative Me2AsSR is metabolized by C. humicola to Me3As and Me2AsH, but some other Me2AsSR′ compounds are unaffected. Studies involving the interaction of the arsenic(III) compounds with natural ecosystems and other micro-organisms such as Scopulariopsis brevicaulis, Straptococcus sanguis, Escherichia coli, and Veillonella alcalescens are described.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590030107
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