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Enhanced toxicity of the immunosuppressant ovalicin upon application to the skin (1988)

Stähelin, H.

Springer

Cellular and molecular life sciences 44 (1988), S. 611-613

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ISSN: 1420-9071

Keywords: Ovalicin ; immunosuppression ; toxicity ; metabolic toxification ; skin

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The non-myelotoxic immunosuppressive sesquiterpene ovalicin, of fungal origin, is much more toxic when applied to the skin of animals than when injected i.v., the LD-50 in guinea pigs being 0.2 in the first case and 7 mg/kg in the second. It elicits aphagia and adipsia. It is assumed that ovalicin effects are due to slow, tissue-specific, metabolic toxification.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01953314

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