ISSN:
1573-6881
Keywords:
Patch clamp
;
planar membranes
;
liver mitochondria
;
heart mitochondria
;
liposomes
;
ion channel
;
IMM channel (inner mitochondrial membrane channel)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Physics
Notes:
Abstract By use of the patch-clamp technique, the inner membrane of mouse liver and heart mitochondria is shown to contain a highly conductive (around 100 pS in symmetrical 150 mM KCl) and voltage-dependent ion channel. This channel closely resembles that previously found in cuprizone-treated mouse liver inner mitochondrial membrane. The paper discusses the electrical properties of the channel and its possible physiological function. The reconstitution in giant liposomes of a partially purified ox heart inner membrane fraction containing the channel and the use of various inhibitors are also presented.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00762520
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