ISSN:
1573-4927
Keywords:
esterase-16
;
rat genetics
;
linkage group V (LGV)
;
cluster 2
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract Esterase-16, an esterase present in lung and other tissues of the laboratory rat, has been characterized by its biochemical properties (electrophoretic mobility, substrate pattern, sensitivity to inhibitors) and genetic variation in 107 inbred strains and substrains including 14 RI strains. It was classified as a carboxylesterase (EC 3.1.1.1). The phenotype ES-16A (BN/Han and 63 other strains) was defined as a narrow electrophoretic band migrating between ES-1A and ES-13A, ES-16B (LEW/Han and 42 other strains) exhibited the same electrophoretic mobility as ES-16A but was distinguished by its extremely weak activity. Segregation of ES-16 in RI strains and backcrosses indicated linkage to linkage group V (LGV). TheEs-16 locus was tentatively placed into esterase cluster 2 and homology withEs-7 of the house mouse is proposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02399605
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