ISSN:
1573-8744
Keywords:
ethyl alcohol
;
kinetics of elimination from human blood
;
Michaelis-Menten equation
;
oral administration with food to a single subject
;
area under the blood alcohol curve
;
absorption efficiency component
;
component due to absorption rate and Michaelis-Menten kinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Whole capillary blood ethanol concentrations following the oral administration of a 30-ml dose of absolute alcohol (0.32 g/kg absolute alcohol) and 45-ml doses of 95% alcohol (0.45 g/kg absolute alcohol) under varying test meal conditions to an adult male volunteer were measured. Ten different test conditions were two fasting (30 ml and 45 ml), three liquid test meals (45 ml), and five solid test meals (45 ml). The terminal concentration-time data were simultaneously fitted to a modification of the integrated form of the Michaelis-Menten equation. The parametersV m andK m of the Michaelis-Menten equation obtained in this fitting were very close to the average values of these parameters following the constant-rate intravenous infusion of ethanol to six adult male volunteers in another study. The area under the concentration-time curves following the liquid and solid food test meals decreased with an increase in the size of the meal. The reduction in area caused by food was the result of two factors: (a) decrease in efficiency of absorption (average 55%) and (b) slowing of the absorption rate coupled with the operation of Michaelis-Menten elimination kinetics (average 45%).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01064808
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