ISSN:
0197-8462
Keywords:
baboon (Papio cynocephalus)
;
interleukin 2
;
mitogen response
;
peripheral blood lymphocytes
;
T helper/suppressor cell ratio
;
Life and Medical Sciences
;
Occupational Health and Environmental Toxicology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Physics
Notes:
In a pilot immunology experiment, peripheral blood samples from six baboons (Papio cynocephalus) housed as a social group were collected during week 5 of preexposure, exposure, and postexposure periods that were each 6 weeks in duration. The subjects were exposed to vertical 6 kV/m and horizontal 50 μT (0.5 G) fields for 12 h per day. Lymphocytes collected during the exposure period displayed statistically significant (P 〈.05) reductions in CD3+ and CD4+ counts, interleukin 2 receptor expression, and proliferative response to pokeweed mitogen. A second experiment was conducted using samples from seven subjects exposed to 30 kV/m and 100 μT (1.0 G) and eight sham-exposed subjects. Statistically significant Period × Group interactions occurred for total white blood cell count and CD4+ to CD8+ ratio, but the pattern of results was not suggestive of an exposure-related effect. Although components of the nonhuman primate immune system appear to be affected by 60 Hz electric and magnetic field exposure in one of two experiments, additional experiments are required to evaluate this possibility. © 1995 Wiley-Liss, Inc.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bem.2250160709
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