ISSN:
1432-1041
Schlagwort(e):
drug metabolism
;
interferon-α
;
7-alkoxycoumarin O-dealkylation
;
hepatitis B
;
human liver biopsy
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary The depressant effect of interferon-α on drug metabolizing activity in the liver has been investigated in 12 patients with chronic active hepatitis B. 7-methoxy-coumarin (7-MC) O-demethylase and 7-ethoxycoumarin (7-EC) O-deethylase, in specimens obtained by liver biopsy, were measured before and after interferon treatment. 7-MC and 7-EC O-dealkylase activity were significantly reduced after interferon treatment, from 13.4 to 9.24 nmol·g−1 liver·min−1, and from 3.22 to 2.16 nmol·g−1 liver·min−1, respectively. The magnitude of the fall varied widely between individual patients. The study provides the first direct evidence that interferon-α can impair the activity of drug metabolizing enzymes in the human liver.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00315411
Permalink
