ISSN:
1573-1111
Keywords:
β-Cyclodextrin
;
ketoprofen
;
hydration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The ketoprofen/beta-cyclodextrin (β-CD) inclusion compounds may be conveniently obtained through a solid state reaction at room temperature in the presence of saturated water vapour. Relative to the corresponding complexes produced with the usual coprecipitation method, the new compounds have a higher ketoprofen content and/or different properties. In particular, the formation reaction is not accompanied by a loss of hydration water, which is released in distinct stages upon heating. The thermodynamics of the dehydration process is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008020910028
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