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  • 1
    Electronic Resource
    Electronic Resource
    4-Aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices (1991)
    Springer
    Cellular and molecular life sciences 47 (1991), S. 254-257 
    Details
    ISSN: 1420-9071
    Keywords: Carbamazepine ; potassium ; hippocampus ; epilepsy ; electrophysiology ; 4-aminopyridine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 μM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01958152
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of carbamazepine actions in hippocampal slices of the rat (1983)
    Springer
    Cellular and molecular neurobiology 3 (1983), S. 213-222 
    Details
    ISSN: 1573-6830
    Keywords: carbamazepine ; hippocampus ; complex partial epilepsy ; trigeminal neuralgia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Carbamazepine at therapeutic concentrations has a strong inhibitory effect on the spontaneous field bursts of the CA 1 region of rat hippocampal slices in low-Ca2+, high-Mg2+ solution. 2. A reduction of excitability and synaptic transmission as well as no effect on posttetanic potentiation in the rat hippocampal slice by carbamazepine agrees with previous studies on spinal cord and peripheral nerve. 3. Carbamazepine left synaptic inhibition and hyperpolarizing afterpotentials unaltered while these inhibitory processes were markedly enhanced by pentobarbital and adenosine, respectively. 4. The spontaneous field bursts are, at least in part, synchronized by ephaptic transmission and may serve as a model of epilepsy and trigeminal neuralgia. The clinical effectiveness of carbamazepine in these two ailments may be explained by a suppression of this pathological synchronization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710948
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    Paper (German National Licenses)
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