Publikationsdatum:
2015-03-31
Beschreibung:
We report a synthetic methodology for the construction of the fused heterocyclic compounds pyrido[2,1- b ]quinazolin-9(1 H )-ones and pyrrolo[2,1- b ]quinazolin-9(1 H )-ones through an AgOTf-catalyzed intramolecular alkyne hydroamination reaction. The methodology is applicable to a wide scope of substrates and produces a series of fused quinazolinone heterocycles in good to excellent yields. Beilstein J. Org. Chem. 2015, 11, 416–424. doi:10.3762/bjoc.11.47
Schlagwort(e):
heterocyclic moleculesintramolecular alkyne hydroaminationsilver
Digitale ISSN:
1860-5397
Thema:
Chemie und Pharmazie
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