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  • 1
    Electronic Resource
    Electronic Resource
    An early effect of aflatoxin B1 administered in vivo on the growth of bone marrow CFU-GM and the production of some cytokines in rats (1992)
    Springer
    Mycopathologia 120 (1992), S. 113-119 
    Details
    ISSN: 1573-0832
    Keywords: Aflatoxin B1 ; colony-stimulating activity ; granulopoiesis ; interleukin-1 ; interleukin-2
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Our data demonstrate the granulopoietic toxicity of aflatoxin B1 (AFB1)in vivo and show an impact of this mycotoxin on the production of some humoral regulatory factors dealing with the granulopoietic developmental pathway (CSA, IL-1, IL-2). The dose of AFB1 studied represented approximately 1/5 of LD50 for young male rats. An early suppressive effect of AFB1 towards CFU-GM was transient in treated animals. The peak in granulopoietic activity was preceded in time by an increased CSA and IL-1 formation. Elevated IL-2 synthesis and increased T cell activation paralleled the peak in granulopoietic activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00578296
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