ISSN:
1573-4919
Keywords:
caveolae
;
caveolin
;
DARPP32
;
glycogen
;
protein phosphorylation
;
Protein Targeting to Glycogen (PTG)
;
type I protein serine/threonine phosphatase (PP1)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Insulin is a potent stimulator of intermediary metabolism, however the basis for the remarkable specificity of insulin's stimulation of these pathways remains largely unknown. This review focuses on the role compartmentalization plays in insulin action, both in signal initiation and in signal reception. Two examples are discussed: (1) a novel signalling pathway leading to the phosphorylation of the caveolar coat protein caveolin, and (2) a recently identified scaffolding protein, PTG, involved directly in the regulation of enzymes controlling glycogen metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006835430797
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