ISSN:
0268-2605
Keywords:
Methylation
;
germanium
;
methyliodide
;
methylcobalamin
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Inorganic germanium(II) in micromolar concentrations was reacted with methyl iodide (CH3I) and methylcobalamin (CH3-CoB12) at various pH values and with different salt matrices. In all experiments monomethylgermanium was the only product. The reaction with CH3-CoB12 at pH 1 yielded approximately 1.3% of the added germanium, whereas no methylation occurred at pH 7. Reaction yields with CH3I were lowest at pH 1 in 0.1 mol dm-3 KCl (1.6%) and highest at pH 7.6 in artificial seawater (6%). For the reaction of CH3-CoB12 with germanium(II) a free-radical mechanism is assumed, whereas methylation by CH3I is most likely an oxidative addition mechanism.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aoc.590060210
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