ISSN:
1573-0603
Keywords:
genetic toxicology testing
;
toxicity screening
;
metabolic activation
;
test standards
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary A survey conducted to determine methods of choice for providing procarcinogen activation and treatment protocols for mammalian cell tests in various genetic toxicology testing laboratories showed that one-third of respondents were performing assays without exogenous activation systems, one-third used liver homogenate preparations with short exposure to the test compound, and one-third used cocultivation with metabolically competent cells with longer exposure times. Treatment protocols were variable even among similar assays, indicating that development of standard operating procedures is still in progress, or may need to be individually defined for different test systems.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01834628
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