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  • frusemide  (1)
  • pharmacogenetics  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Variance comparison as a tool in clinical pharmacology: An example with two loop diuretics (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 221-224 
    Details
    ISSN: 1432-1041
    Keywords: frusemide ; piretanide ; variance comparison ; regularity of effect ; activity comparison ; drug excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Comparison of variances can be useful in assessing the regularity of drug effects. In order to compare the variances of the saluretic effects of piretanide and frusemide, two loop diuretics with different bioavailabilities, a double-blind cross-over study was carried out in 34 normal volunteers. The diuretics were given in randomized order, with an interval of 7 days, in single equipotent doses (frusemide 6.25 mg and piretanide 1.0 mg chosen from previous results) adjusted by body weight. The dispersion of individual values (comparison of variances from paired measures) for Na+, Cl− and Ca++ excretion, urine osmolality and excretion of the drugs, was significantly smaller for piretanide than for frusemide. It is concluded that the saluretic effect of a single dose of piretanide varies less than that of an equipotent dose of frusemide. The methodology may be useful in trials of drugs for which regularity of effect is important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547557
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  • 2
    Electronic Resource
    Electronic Resource
    Acetylator phenotype and congenital malformations (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 151-153 
    Details
    ISSN: 1432-1041
    Keywords: pharmacogenetics ; acetylator phenotype ; congenital anomalies/-heart disease ; facial cleft ; spina bifida
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A further control group was the fathers of the malformed newborn. The malformations studied were facial cleft, spina-bifida and congenital heart disease. The acetylator phenotype was shown not be modified by pregnancy. 49 of 100 (49%) control women were rapid acetylators. Amongst the 108 mothers of malformed babies, 56 (52.8%) were slow acetylators and 52 (47.2%) were fast acetylators, 42 out of 83 (50.5%) of the fathers of malformed were slow acetylators and 41 (49.5%) were fast acetylators. Thus, the acetylator phenotype of the mothers of malformed children is no different from the acetylator phenotype of controls.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609187
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