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  • 1
    Electronic Resource
    Electronic Resource
    Superoxide dismutase activity of the captopril-iron complex (1995)
    Springer
    Molecular and cellular biochemistry 146 (1995), S. 45-47 
    Details
    ISSN: 1573-4919
    Keywords: captopril ; superoxide anion ; iron ; chelating reagent ; ischemia-reperfusion injury ; free radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract With an assay that generates superoxide anion radicals without the intervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydryl group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O· 2 − directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide anion; a result that may help to understand the free radical-scavenging properties of captopril.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926880
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