ISSN:
1573-904X
Keywords:
fat substitutes
;
sucrose polyester
;
tricarballylate triester
;
cyclosporin
;
intestinal absorption
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The effect of non-absorbable fat substitutes (sucrose polyester (SPE) and tricarballylate triester (TCTE)) on cyclosporin A (CsA) intestinal absorption was studied in the rat using in situ perfusion and gastric intubation techniques. A first experiment using the re-circulating intestinal perfusion model showed that emulsions of either 5% SPE or TCTE significantly reduced (p 〈 0.0008) CsA absorption, whereas no difference was found between results for saline and 5% olive oil emulsion. In single-pass intestinal perfusion experiments SPE dose-dependently inhibited CsA absorption at SPE concentrations of 0.31% (p〈 0.0004) and higher. Using gastric intubation, whole blood CsA concentrations significantly decreased when administered with SPE and TCTE in comparison with olive oil (p 〈 0.04). These results confirm that the CsA fraction dissolved in the undigested oil phase, constituted by the undigested and non-absorbed fat substitute, is unavailable for intestinal absorption.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018904225165
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