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  • enzyme inhibitors  (1)
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    Electronic Resource
    Electronic Resource
    Total Synthesis of the Trehalase Inhibitor Salbostatin (1995)
    Weinheim : Wiley-Blackwell
    Chemistry - A European Journal 1 (1995), S. 634-636 
    Details
    ISSN: 0947-6539
    Keywords: carbasugars ; cyclitols ; enzyme inhibitors ; salbostain ; total syntheses ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The total synthesis of trehalase inhibitor salbostatin (1), recently discovered as a novel metabolite of Streptomyces albus species, has been achieved starting from the major product (58 % yield) from the coupling of the amine di-O-isopropylidene-α-valienamine and the electrophile 1,5 : 2,3-dianhydro-D-mannitol in 2-propanol. Deprotection with aqueous acetic acid and subsequent purification on a column of acidic resin afforded 1, which showed inhibitory activity (IC50 = 8.3 μML-1) against silkworm trehalase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chem.19950010911
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