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  • dopamine receptor subtypes  (1)
  • schizophrenia  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system (1989)
    Springer
    Cellular and molecular neurobiology 9 (1989), S. 1-44 
    Details
    ISSN: 1573-6830
    Keywords: depression ; schizophrenia ; tardive dyskinesia ; antidepressants ; neuroleptics ; biogenic amines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. A review of the effects of long-term administration of antidepressants and neuroleptics on receptors in the central nervous system is presented. 2. The effects of antidepressants on adenylate cyclase activity and on receptor binding in brain tissue are discussed. Effects on a variety of receptor types are considered. 3. The utilization of electrophysiological, behavioral, and neurochemical studies to assess receptor function after chronic antidepressant administration is discussed, as is the use of peripheral receptor estimations in clinical studies. 4. Animal studies on the actions of chronic administration of neuroleptics on pre- and postsynaptic dopamine receptors are reviewed. Effects of these drugs on dopamine receptors in humans are considered from the following perspectives: postmortem andin vivo binding studies in schizophrenia, tardive dyskinesia, and central versus peripheral receptor estimation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711441
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of chronic antidepressant treatment on dopamine-related [3H]SCH 23390 and [3H]Spiperone binding in the rat striatum (1992)
    Springer
    Cellular and molecular neurobiology 12 (1992), S. 597-606 
    Details
    ISSN: 1573-6830
    Keywords: dopamine receptor subtypes ; [3H]SCH 23390 ; [3H]spiperone ; monoamine oxidase inhibitors ; desipramine ; striatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The effects of chronic administration of antidepressants on dopaminerelated [3H]SCH 23390 and [3H]spiperone binding to rat striatal membranes were assessed. 2. The monoamine oxidase inhibitors phenelzine (5 or 10 mg kg−1/day) and tranylcypromine (1 mg kg−1/day) and the tricyclic desipramine (10 mg kg−1/day) were administered for 28 days by constant subcutaneous infusion using Alzet (2ML4) osmotic minipumps. 3. These treatments did not alterK d estimates for either [3H]SCH 23390 or [3H]spiperone binding sites. The monoamine oxidase inhibitors induced a decrease in theB max values for both [3H]SCH 23990 and [3H]spiperone binding sites. Desipramine induced a decrease in theB max value for [3H]SCH 23390 binding but had no effect on theB max value for [3H]spiperone binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711239
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    Paper (German National Licenses)
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