ISSN:
1432-1041
Keywords:
nifedipine
;
plasma concentrations
;
distribution
;
debrisoquine phenotype
;
retard preparation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Variations in plasma nifedipine concentrations have been reported and one study has suggested the existence of a subpopulation of poor metabolisers of this drug. We have studied the variability of 12 h plasma nifedipine concentrations in 64 hypertensive patients on long-term nifedipine Retard 20 mg twice daily. A slightly skewed unimodal distribution with a modal concentration of 15 to 30 ng/ml was obtained. No relationship between 12-h plasma levels and debrisoquine hydroxylation phenotype was found.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00543967
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