ISSN:
1573-8221
Keywords:
thymus
;
spleen
;
proliferation
;
cytolytic T lymphocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The proliferative and cytolytic activity of lymphocytes from the spleen and intact thymus was compared after alloimmunization. The number of living cells and of DNA-synthesizing cells in a monoculture of thymocytes was 90–97% less, and in a mixed culture of thymus cells about 80% less that the corresponding number of spleen cells. The index of stimulation of immune thymocytes was several times greater than that of immune spleen cells. The peak of cytotoxicity was observed on the fourth to fifth day of stimulation, when the cytolytic activity of the immune thymocytes was close to the activity of immune spleen cells. The low DNA synthesis and the considerable cytotoxic activity of the immune thymocytes mean that stimulation of thymus cells in vitro can be used to obtain a cell population with a high content of cytolytic T lymphocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00805893
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