ISSN:
1573-8221
Keywords:
streptococcus
;
A-polysaccharide
;
monoclonal antibodies
;
cross-reacting antigens
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Hybridomas producing monoclonal antibodies intensively reacting with group A streptococcus antigens in enzyme immunoassay were obtained as a result of immunizing mice with pepsin-treated cultures of group A streptococcus. All antibodies were referred to class M immunoglobulins. The reactions of monoclonal antibodies were completely inhibited by the pepsin-treated culture of group A streptococcus. The degree of inhibition with A-polysaccharide was lower, being 17.5 to 50.0 in different monoclonal antibodies. All the monoclonal antibodies obtained cross-reacted with antigens of murine and human epithelial tissues of the thymus and skin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02444621
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