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Recombinant Tissue Plasminogen Activator: A Brief Review (1987)

Grossbard, Elliott B.

Springer

Pharmaceutical research 4 (1987), S. 375-378

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ISSN: 1573-904X

Keywords: thrombolytic ; tissue plasminogen activator ; plasminogen activators ; coronary thrombolysis

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract Thrombolytic therapy has received renewed attention with the demonstration that early treatment of acute myocardial infarction with plasminogen activators can reduce mortality. Tissue plasminogen activator (t-PA) is a protein with attributes that may allow for greater efficacy and safety. Recombinant DNA technology has enabled the production of sufficient t-PA, called rt-PA (Activase), for substantial clinical evaluation. The results suggest that Activase is a significant advance in thrombolytic therapy.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1023/A:1016474026501

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