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Structure of a gap junction gene: Rat connexin-32 (1988)

Miller, Todd ; Dahl, Gerhard ; Werner, Rudolf

Springer

Bioscience reports 8 (1988), S. 455-464

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ISSN: 1573-4935

Keywords: connexin ; gap junction ; gene structure

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract A genomic clone for the rat liver gap junction protein (connexin-32) was isolated and characterized by restriction enzyme mapping and sequence analysis. While the complete coding sequence is contained within one uninterrupted block, the 5′-untranslated region of the transcript contains a 6.1 kb intron. Both S1 nuclease protection and primer extension assays indicate multiple transcription start sites. Sequences homologous to cAMP response elements are found near the transcription start sites and within the 3′-end of the intron.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01121644

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