ISSN:
1573-6849
Keywords:
chromosome arms
;
chromosome structure
;
chromosome territories
;
confocal microscopy
;
fluorescence in situ hybridization
;
nuclear organization
;
random walk/giant loop model
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract Fluorescence in situ hybridization (FISH) with microdissection probes from human chromosomes 3 and 6 was applied to visualize arm and subregional band domains in human amniotic fluid cell nuclei. Confocal laser scanning microscopy and quantitative three-dimensional image analysis showed a pronounced variability of p- and q-arm domain arrangements and shapes. Apparent intermingling of neighbouring arm domains was limited to the domain surface. Three-dimensional distance measurements with pter and qter probes supported a high variability of chromosome territory folding.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009262223693
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