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  • chemical modification  (1)
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    Electronic Resource
    Electronic Resource
    Linking radiometals to proteins with bifunctional chelating agents (1984)
    Springer
    The protein journal 3 (1984), S. 215-228 
    Details
    ISSN: 1573-4943
    Keywords: metals ; antibodies ; chelates ; chemical modification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Bifunctional chelating agents contain a metal chelating group and a second functional group that is usually chemically reactive in nature. They allow stable attachment of radioactive metal ions to proteins and other biological molecules, for use as radiopharmaceuticals and in other applications. Their chemical synthesis, attachment to proteins, and reaction with metals are briefly reviewed. Propertiesin vivo of chelate-tagged transferrin, chelate-tagged antibody to the transferrin cell-surface receptor, and111indium-transferrin are compared.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01040501
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