ISSN:
1435-1536
Keywords:
Stratum corneum liposomes
;
stratum corneum liposomes/surfactant interactions
;
permeability alteration
;
carboxyfluorescein release
;
surfactant/stratum corneum lipids molar ratios
;
surfactant partition coefficients
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Abstract The alterations caused by the surfactants sodium dedecyl sulfate (SDS); sodium dodecly ether sulfate (SDES); Triton X-100 (OP-10EO) and dodecyl betaine (D-Bet) in the permeability of liposomes formed by a lipid mixture modeling the stratum corneum composition (40% ceramides, 25% cholesterol, 25% plamitic acid and 10% cholesteryl sulfate) were investigated. The SC liposomes/surfactant sublytic interactions were mainly ruled by the action of surfactant monomers in all cases. The OP-10EO showed the highest ability to alter the permeability of bilayers and the highest affinity with these structures, whereas D-Bet showed the lowest tendencies. Although SDS and SDES exhibited similar activity at 50% CF release (similar Re values), the SDES appeared to be more active at 100% CF release, its affinity with bilayers being also increased. Different trends in the evolution of Re andK were observed when comparing the results obtained with those reported for phosphatidylcholine (PC) liposomes. Thus, whereas SC liposomes were more resistant to the action of surfactants, the surfactant affinity with SC bilayers was always greater than that reported for PC ones.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01188949
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