ISSN:
0749-1581
Keywords:
1H NMR
;
2,6-disubstituted 6-carbamoyl-5,6-dihydro-2H pyrans
;
carbamoyl group, reverse anomeric effect
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The 1H NMR spectra of 2,6-disubstituted 6-carbamoyl-5,6-dihydro-2H-pyrans and their 6-methoxycarbonyl analogs have been recorded. With the use of coupling constants between ring protons, the conformational preference of the carbamoyl group has been evaluated. The 1H6⇌6H1 conformational equilibria in the above compounds are discussed. It is found that the conformational tendency of the carbamoyl group to the equatorial disposition helps to determine the conformational equilibrium in the seven examples studied.
Additional Material:
1 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260250215
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