ISSN:
1432-1041
Keywords:
Carbamazepine
;
Paediatric patient
;
Epilepsy
;
carbamazepine-10,11-epoxide
;
specific-nonspecific binding
;
protein binding
;
age effect
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The in vivo serum protein binding characteristics of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) were assessed in sera from 23 paediatric patients on CBZ monotherapy. We assumed that CBZ and CBZ-E binding to serum proteins comprised specific binding sites on α1-acid glycoprotein (AAG) and non-specific binding sites on serum albumin. Therefore, the binding characteristics of each compound were analysed according to specific and nonspecific binding equations. Association constants for drug-AAG binding were 0.096 l·μmol−1 for CBZ and 0.023 l·μmol−1 for CBZ-E. Within the concentration ranges investigated the specific binding of each compound contributes to the drug-serum protein interactions. Age did not show a significant correlation with the serum unbound fraction of each compound.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00271375
Permalink
