ISSN:
1572-8943
Keywords:
cancerogenic and anticancerogenic compounds
;
microcalorimetry
;
tumor cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The influence of mitoxantron (M) and benz(a)pyrene (BP) on chromatin DNA in composition of spleen and liver tissues and cells of BALB/c mice were studied using a high-sensitive differential scanning microcalorimeter. It was established that BP can cause a) the specific breaks in ‘inactive’ chromatin DNA chain and unfolding of the whole domain (a loop of chromatin) which should lead to uncontrolled genome activation; b) the breaks in the DNA double-helix creating short duplexes.M at low doses, interacting with ‘naked’ linker DNA of tumor restores the chromatin structure, at high doses or at repeated injections,M causes the disturbance of chromatin structure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02135020
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