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  • blood-testicular barrier  (1)
  • varicocele  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Autoimmune nature of the disturbance of spermatogenesis in rats with experimental varicocele (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 52-56 
    Details
    ISSN: 1573-8221
    Keywords: varicocele ; spermatogenesis ; autoimmune responses ; blood-testis barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Measured disturbance of the venous outflow from the left testis in rats causes the development of destructive changes in the spermatogenic epithelium both in the testis on the side of the operation and also in the contralateral organ. Disturbances of spermatogenesis in rat testes (foci of desquamation of spermatogenic epithelium, disorganization and degeneration of the sex cells, emptying of the seminiferous tubules) are similar to those in men with varicocele, so that the results of such experiments can be regarded as an experimental model of varicocele. In the experimental rats the permeability and fine structure of the blood-testis barrier were disturbed in both testes, the pattern of the morphological changes was similar with that observed during the development of autoimmune orchitis, and lymphocytes sensitized to spermatozoal antigens were found in the lymphoid organs. Taken as a whole, the results suggest involvement of immunologic mechanisms in the development of the pathological changes in the testes in varicocele.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00802352
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  • 2
    Electronic Resource
    Electronic Resource
    Prevention of development of post-traumatic atrophy of the rat testis by injection of aspirin (1974)
    Springer
    Bulletin of experimental biology and medicine 78 (1974), S. 1181-1184 
    Details
    ISSN: 1573-8221
    Keywords: aspirin ; testicular atrophy ; blood-testicular barrier
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The left testis was punctured with a needle (diameter 3 mm) in 42 sexually mature Wistar rats. The development of atrophy of the testis was observed 12 days after the operation in control animals receiving “empty” suppositories: the weight of the injured organ was greatly reduced, the seminiferous tubules of the whole testis were empty, their spermatogenic epithelium had undergone degeneration or destruction, the permeability of the blood-testicular barrier (BTB) for endogenous globulins was increased, and sharp changes were found in the ultrafine structure of the principle components of the barrier — the tunica propria of the seminiferous tubules and the Sertoli cells. After injection of aspirin (0.5 g daily for 5 to 12 days) into the rats the development of post-traumatic atrophy of the testes was not observed. The aspirin had no effect on the character and intensity of pathological processes developing in the focus of injury, but it prevented the spread of destructive changes to the intact part of the testis and disturbance of the permeability of the BTB away from the region of injury. The effect of aspirin on the development of post-traumatic testicular atrophy is evidently connected with its inhibitory action on prostaglandin synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804632
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    Paper (German National Licenses)
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