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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of ethanol after oral administration in the fasting state (1977)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 5 (1977), S. 207-224 
    Details
    ISSN: 1573-8744
    Keywords: nonlinear pharmacokinetics ; Michaelis-Menten kinetics ; gastric emptying rate ; blood alcohol concentrations
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A nonlinear relationship between the total area under the blood ethanol concentration-time curve and the orally administered dose (mg/kg) of ethanol was observed in fasting subjects. A preliminary model, based on physiological considerations, was elaborated and shown, for the first time, to describe the entire time course of blood alcohol concentrations after four different doses of alcohol. The model could be refined by further experimentation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01065396
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  • 2
    Electronic Resource
    Electronic Resource
    Fasting and nonfasting blood ethanol concentrations following repeated oral administration of ethanol to one adult male subject (1977)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 5 (1977), S. 41-52 
    Details
    ISSN: 1573-8744
    Keywords: ethyl alcohol ; kinetics of elimination from human blood ; Michaelis-Menten equation ; oral administration with food to a single subject ; area under the blood alcohol curve ; absorption efficiency component ; component due to absorption rate and Michaelis-Menten kinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Whole capillary blood ethanol concentrations following the oral administration of a 30-ml dose of absolute alcohol (0.32 g/kg absolute alcohol) and 45-ml doses of 95% alcohol (0.45 g/kg absolute alcohol) under varying test meal conditions to an adult male volunteer were measured. Ten different test conditions were two fasting (30 ml and 45 ml), three liquid test meals (45 ml), and five solid test meals (45 ml). The terminal concentration-time data were simultaneously fitted to a modification of the integrated form of the Michaelis-Menten equation. The parametersV m andK m of the Michaelis-Menten equation obtained in this fitting were very close to the average values of these parameters following the constant-rate intravenous infusion of ethanol to six adult male volunteers in another study. The area under the concentration-time curves following the liquid and solid food test meals decreased with an increase in the size of the meal. The reduction in area caused by food was the result of two factors: (a) decrease in efficiency of absorption (average 55%) and (b) slowing of the absorption rate coupled with the operation of Michaelis-Menten elimination kinetics (average 45%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01064808
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    Paper (German National Licenses)
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