ISSN:
1573-8744
Keywords:
biliary recycling
;
bioavailability
;
biotransformation
;
clearance
;
route dependence
;
enterohepatic circulation
;
indomethacin
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract There are no discernible quantitative differences in the biotransformation and the excretion of indomethacin following oral, rectal, and intravenous administration of indomethacin-14 C. Approximately 50% (range 24–115% for n=6) of an intravenous dose undergoes enterohepatic circulation. Thus the bioavailability of indomethacin to the systemic circulation may exceed the administered dose. Relative to the intravenous dose, indomethacin is 80 and 100% bioavailable from suppositories and capsules, respectively. Absorption and/or reabsorption appears to be more rapid and uniform by the rectal route. Recognition of the attributes of biliary recycling also helps to explain the observed variability in apparent plasma half-life, while their neglect requires alternative explanations for anomalies between the disappearance rate from plasma and the corresponding appearance rate in urine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01063617
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