ISSN:
0006-3525
Keywords:
base flipping
;
extrahelical nucleotide
;
DNA methyltransferases
;
DNA repair enzymes
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Rotation of a DNA nucleotide out of the double helix and into a protein binding pocket (“base flipping”) was first observed in the structure of a DNA methyltransferase. There is now evidence that a variety of proteins, particularly DNA repair enzymes, use base flipping in their interactions with DNA. Though the mechanisms for base movement into extrahelical positions are still unclear, the focus of this review is how base recognition is modulated by the stringency of binding to the extrahelical base(s) or sugar moiety. © 1997 John Wiley & Sons, Inc. Biopoly 44: 139-151, 1997
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
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